Why is omeprazole used in the management of cystic fibrosis?

Omeprazole is used in the management of cystic fibrosis primarily to manage stomach acidity. In patients with cystic fibrosis, pancreatic insufficiency is common, which can lead to malabsorption of nutrients as well as digestive issues. To help in the digestion of food, pancreatic enzymes are often prescribed. However, the presence of excess stomach acidity can interfere with the efficacy of these enzymes, as they function optimally in a less acidic environment.

By reducing stomach acidity, omeprazole helps to create a more favorable condition for the pancreatic enzymes to work effectively, thereby improving nutrient absorption and overall digestive health. This is particularly important in cystic fibrosis management, where maintaining adequate nutrition is crucial for growth and lung health.