Which syndrome is characterized by uncomfortable sensations in the legs that lead to movement?

Restless leg syndrome is characterized by uncomfortable sensations in the legs, often described as crawling, tingling, or aching feelings, which lead to a strong urge to move the legs to alleviate these sensations. This condition typically occurs during periods of rest or inactivity, especially in the evening or at night, and is frequently relieved by movement. Patients may find temporary relief through walking, stretching, or any form of leg movement.

The other conditions listed have distinct symptoms that do not primarily involve the uncomfortable sensations in the legs. Rett syndrome is a neurological disorder that predominantly affects girls and is characterized by loss of purposeful hand skills, language development, and gait. Tourette's syndrome involves repetitive, involuntary movements and vocalizations (tics) that are not specifically related to discomfort in the legs. Ekbom's syndrome, also known as delusional parasitosis, is more about the false belief of being infested with parasites rather than a sensation in the limbs. Thus, restless leg syndrome is the correct answer as it aligns directly with the definition given in the question.