Which symptom typically follows the high-grade fever in roseola infantum?

In roseola infantum, also known as sixth disease, the clinical presentation is characterized by a sudden onset of high-grade fever, which can last for three to five days. Following this fever, a distinctive rash appears, typically starting on the trunk before spreading to other areas.

The rash in roseola is generally maculopapular, meaning it consists of both macules (flat red spots) and papules (small raised bumps). This type of rash may also be described as a generalized rash because it can cover a significant area of the body, although it is most prominent on the trunk. It usually develops as the fever resolves, indicating the conclusion of the illness. The appearance of the rash after the fever is a classic sign of the condition, providing key information for diagnosis.

Given this sequence of symptoms and the nature of the rash, it is appropriate to identify the maculopapular rash on the trunk as the typical symptom that follows the high-grade fever in roseola infantum.