Which of the following physical features is commonly seen in individuals with Down syndrome?

Individuals with Down syndrome, also known as trisomy 21, often exhibit characteristic physical features that can aid in diagnosis. One of the hallmark features is up-slanting palpebral fissures, which refers to the upward tilt of the openings of the eyes. This feature is a distinct trait associated with Down syndrome and is believed to result from the atypical development of the facial structure during gestation.

The up-slanting appearance is in conjunction with other facial characteristics such as a flat nasal bridge and a small mouth, which contribute to the overall facial profile commonly observed in individuals with this condition. The presence of this specific eye morphology is frequently noted in medical assessments and genetics evaluations related to Down syndrome.

In contrast, other physical features listed, such as a prominent forehead, long limbs, and a square chin, are not typically associated with Down syndrome. Individuals with Down syndrome commonly have shorter stature and may exhibit a more rounded physical appearance, rather than long limbs or a prominent forehead. Understanding these features can be significant for accurate identification and support for individuals with Down syndrome.