Which condition typically presents with obstructive jaundice after the third week of life?

Biliary atresia is the condition that typically presents with obstructive jaundice after the third week of life. It is a serious condition where the bile ducts are either absent or malformed, leading to obstruction of bile flow from the liver to the intestine. As a result, bile accumulates in the liver, causing conjugated hyperbilirubinemia and obstructive jaundice. This usually presents within the first few months of life, often becoming noticeable after three weeks, and requires prompt diagnosis and management, often involving surgical intervention.

Physiological jaundice and breast milk jaundice both primarily occur within the first few weeks of life but are generally associated with unconjugated hyperbilirubinemia. Physiological jaundice is a normal process that resolves on its own, while breast milk jaundice can occur due to substances in breast milk affecting bilirubin metabolism, but it still typically does not present as obstructive jaundice.

Hemolytic disease of the newborn is associated with destruction of red blood cells, leading to unconjugated hyperbilirubinemia and jaundice, usually appearing in the first few days of life rather than after three weeks. In contrast, biliary atresia's later onset and relationship with obstructive jaundice make it