Which condition is associated with jaundice and chronic cough?

The condition associated with jaundice and chronic cough is alpha-1-antitrypsin deficiency. This genetic disorder leads to insufficient production of the alpha-1-antitrypsin protein, which protects the lungs and liver from damage. Individuals with this deficiency may develop liver disease due to the accumulation of the abnormal protein, leading to jaundice as a result of liver dysfunction. In addition, they are at an increased risk for lung diseases, particularly emphysema and chronic obstructive pulmonary disease, which can manifest as a chronic cough.

Cystic fibrosis is characterized by thick, sticky mucus in various organs, primarily affecting the lungs and pancreas, leading to respiratory issues and digestive problems but not typically jaundice. Asthma primarily manifests as wheezing and shortness of breath due to airway inflammation, not jaundice. Bronchiolitis, often caused by viral infections in young children, leads to respiratory symptoms but does not present with jaundice. Thus, alpha-1-antitrypsin deficiency uniquely combines both jaundice and chronic cough as presenting features.