What laboratory findings would you expect in a child suffering from Thrombotic Thrombocytopenic Purpura?

In a child suffering from Thrombotic Thrombocytopenic Purpura (TTP), the expected laboratory findings primarily include thrombocytopenia and signs of significant hemolysis. TTP is characterized by a triad of symptoms: microangiopathic hemolytic anemia, thrombocytopenic purpura, and organ dysfunction, particularly affecting the kidneys and brain.

Thrombocytopenia is a critical feature because the condition leads to the consumption of platelets due to the formation of microthrombi in the circulation. As these microthrombi form, they shear red blood cells, resulting in hemolysis. This hemolysis can be evidenced by laboratory findings such as elevated levels of indirect bilirubin, low haptoglobin, and the presence of schistocytes on a blood smear, confirming the hemolytic component of the disease.

The correct answer highlights these pivotal aspects of TTP, where the combination of reduced platelet count and signs of hemolysis is indicative of the underlying pathophysiology.

The other choices do not align with the primary laboratory findings in TTP. A high white blood cell count may not necessarily be present and is more indicative of infection or inflammation. Elevated liver enzymes may