What is a key clinical feature that differentiates cystic fibrosis from celiac disease?

A key clinical feature that differentiates cystic fibrosis from celiac disease is the presence of frequent respiratory infections. Cystic fibrosis primarily affects the respiratory and digestive systems due to a mutation in the CFTR gene, leading to the production of thick, viscous mucus. This thick mucus obstructs the airways, which creates an environment conducive to chronic respiratory infections and inflammation. Patients with cystic fibrosis often experience recurrent lung infections, which are characteristic of the disease.

In contrast, celiac disease primarily involves an immune response to gluten, resulting in gastrointestinal symptoms such as diarrhea, weight loss, and malabsorption, without the prominent respiratory complications that are observed in cystic fibrosis. Therefore, the frequent occurrence of respiratory infections serves as a distinctive feature of cystic fibrosis, helping to differentiate it from celiac disease.