What is a classic facial feature of DiGeorge's syndrome?

A classic facial feature of DiGeorge's syndrome includes dysmorphic features such as a cleft palate. This syndrome is a result of a microdeletion on chromosome 22 and leads to various developmental abnormalities. The characteristic facial features can include palpebral (eyelid) slanting, epicanthic folds, and a shortened philtrum, which often contribute to dysmorphic features. Additionally, the presence of a cleft palate is significant in DiGeorge's syndrome, as it is frequently observed alongside other anomalies, reflecting the underlying developmental disruptions that occur due to the genetic changes associated with the condition.

While other choices may represent features seen in various syndromic conditions, they are not specific to DiGeorge's syndrome. A prominent forehead and protruding tongue are more associated with other syndromes, and facial angiofibromas are typically linked with conditions like tuberous sclerosis, not DiGeorge’s. Thus, the presence of dysmorphic features, including a cleft palate, is a defining characteristic of DiGeorge's syndrome and reflects its developmental impact.