What does the mnemonic CATCH-22 signify in DiGeorge's syndrome?

The mnemonic CATCH-22 in DiGeorge's syndrome highlights key features associated with the condition, which stem from a deletion in chromosome 22. The components of the mnemonic specifically relate to critical aspects of the syndrome.

The "C" stands for cardiac abnormalities, which commonly include issues such as conotruncal anomalies, most notably tetralogy of Fallot and truncus arteriosus. The "A" represents thymic aplasia, which leads to impaired immune function due to the underdevelopment of the thymus gland. This results in an increased susceptibility to infections, particularly from viral and fungal pathogens, since T-cell production is affected.

The "T" indicates the presence of facial abnormalities, which may encompass features like a short palpebral fissure and a broad nasal bridge, although this is not directly included in the answer choice.

Hence, the correct answer encapsulates two of the critical aspects of DiGeorge's syndrome that are central to understanding its clinical presentation and implications. Recognizing these key features helps in diagnosing the syndrome and managing the associated complications effectively.