What common laboratory finding is associated with DiGeorge's syndrome?

DiGeorge's syndrome, also known as 22q11.2 deletion syndrome, is characterized by developmental defects that affect several systems in the body, including the immune system and parathyroid glands. A key laboratory finding associated with this syndrome is hypocalcemia, which results from the deficiency of parathyroid hormone due to underdeveloped or absent parathyroid glands.

The parathyroid glands are responsible for regulating calcium levels in the body through the secretion of parathyroid hormone (PTH). In DiGeorge's syndrome, the hypoplasia or aplasia of these glands leads to inadequate production of PTH, resulting in low calcium levels (hypocalcemia). This finding is significant as it can lead to symptoms such as muscle cramps, tetany, and seizures due to the important role calcium plays in neuromuscular function.

Recognizing hypocalcemia as a common laboratory finding in patients with DiGeorge's syndrome is crucial for timely management, as electrolyte imbalances can have serious clinical implications. Understanding this aspect of the syndrome aids in diagnosing and managing affected individuals effectively.