What age range typically shows regression of skills in a child with Rett syndrome?

Rett syndrome is a neurodevelopmental disorder that primarily affects females, and it is characterized by normal early development followed by a loss of acquired skills, which is known as developmental regression. This regression typically occurs after a period of normal development.

The age range when regression is most commonly observed in children with Rett syndrome is around three to four years. During this critical period, children may begin to lose skills such as purposeful hand use and speech. This regression can be accompanied by signs such as loss of social engagement and development of repetitive hand movements, known as hand-wringing.

Understanding the timing of regression is crucial for parents and healthcare professionals to provide appropriate support and interventions. Early identification of Rett syndrome allows for better management of symptoms and developmental support for the child. Recognizing that regression primarily occurs between three and four years can help in guiding expectations for children with the condition and in planning therapeutic approaches.